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當前位置: 首頁 » 食品資訊 » 外訊導讀 » 歐盟評估轉(zhuǎn)基因黑曲霉菌株NPH生產(chǎn)的3-植酸酶的安全性

歐盟評估轉(zhuǎn)基因黑曲霉菌株NPH生產(chǎn)的3-植酸酶的安全性

放大字體  縮小字體 時間:2024-01-16 11:01 來源:食品伙伴網(wǎng) 作者: 澤夕   
核心提示:2024年1月12日,歐盟食品安全局就一種食品酶3-植酸酶(3-phytase)的安全性評價發(fā)布意見。
   食品伙伴網(wǎng)訊  2024年1月12日,歐盟食品安全局就一種食品酶3-植酸酶(3-phytase)的安全性評價發(fā)布意見。
 
  據(jù)了解,這種食品酶是由轉(zhuǎn)基因黑曲霉菌株NPH生產(chǎn)的,旨在用于三種食品生產(chǎn)過程:烘焙產(chǎn)品、蒸餾酒精以及加工植物和真菌衍生產(chǎn)品以生產(chǎn)植物基牛奶和奶制品類似物。
 
  經(jīng)過評估,專家小組認為,在預期的使用條件下,不能排除通過飲食接觸引起過敏反應的風險(蒸餾酒精生產(chǎn)除外),但這種情況發(fā)生的可能性很低。根據(jù)所提供的數(shù)據(jù),小組得出結(jié)論,該食品酶在預期的使用條件下不會引起安全問題。部分原文報道如下:
 
  The food enzyme 3-phytase (myo-inositol-hexakisphosphate 3-phosphohydrolase EC 3.1.3.8) is produced with the genetically modified Aspergillus niger strain NPH by DSM Food Specialties. The genetic modifications do not give rise to safety concerns. The food enzyme was considered free from viable cells of the production organism and its DNA. It is intended to be used in three food manufacturing processes: processing of cereals and other grains for the production of (1) baked products and (2) distilled alcohol, and the processing of plant- and fungal-derived products for the production of (3) plant-based analogues of milk and milk products. Since no residual amounts of total organic solids (TOS) are carried over into distilled alcohol, dietary exposure was calculated only for the remaining two food manufacturing processes. It was estimated to be up to 0.553 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 833 mg TOS/kg bw per day, the highest dose tested, which, when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 1506. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that the risk of allergic reactions by dietary exposure cannot be excluded (except for distilled alcohol production), but the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.
 
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日期:2024-01-16
 
 
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